A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
Line Number: 127
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$hooks is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$config is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$log is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$utf8 is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$uri is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$exceptions is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$router is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$output is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$security is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$input is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$lang is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$load is deprecated
Filename: core/Controller.php
Line Number: 78
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$db is deprecated
Filename: core/Loader.php
Line Number: 396
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
Line Number: 371
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$table is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 132
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 292
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 166
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 235
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 315
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 356
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 289
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$session is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$agent is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$news_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$home_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Facebook\FacebookApp implements the Serializable interface, which is deprecated. Implement __serialize() and __unserialize() instead (or in addition, if support for old PHP versions is necessary)
Filename: Facebook/FacebookApp.php
Line Number: 29
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/libraries/Facebook/php-graph-sdk-5.x/php-graph-sdk-5.x/src/Facebook/FacebookApp.php
File: /home/judfadzm/public_html/healthtechseries.com/application/libraries/Facebook/php-graph-sdk-5.x/php-graph-sdk-5.x/src/Facebook/autoload.php
File: /home/judfadzm/public_html/healthtechseries.com/application/libraries/Facebook/php-graph-sdk-5.x/php-graph-sdk-5.x/src/Facebook/Facebook.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$facebook is deprecated
Filename: controllers/News.php
Line Number: 31
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$benchmark is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$hooks is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$config is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$log is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$utf8 is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$uri is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$exceptions is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$router is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$output is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$security is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$input is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$lang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$load is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$db is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$table is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$session is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$agent is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$news_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$home_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$facebook is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
Georgiamune and Menarini Group Enter Exclusive Global License and Collaboration Agreement for GIM-621, a First-in-Class Oral Immuno-Oncology Agent
GIM-621 is a preclinical-stage, first-in-class oral small molecule immunotherapy with potential application across multiple solid tumors. Georgiamune to receive $45 million in upfront and near-term payments, as part of a total deal value of up to $1.1 billion, plus royalties. FLORENCE, Italy and GAITHERSBURG, Md. , Oct. 22, 2026 /PRNewswire/ -- The Menarini Group (\"Menarini\"), a leading international pharmaceutical and diagnostics company, and Stemline Therapeutics, Inc. (\"Stemline\"), a wholly-owned subsidiary of the Menarini Group focused on bringing transformational oncology treatments to cancer patients, along with Georgiamune Inc., a clinical-stage biotechnology company discovering and developing first-in-class therapies that reprogram immune signaling pathways to treat cancer and autoimmune diseases, today announced an exclusive worldwide license and collaboration agreement for GIM-621.
GIM-621 is a preclinical-stage first-in-class oral small molecule immunotherapy with potential application across multiple solid tumors. It is one of multiple therapeutic candidates generated from Georgiamune's research into novel mechanisms governing immune activation, suppression and homeostasis.
Under the terms of the license and collaboration agreement, Stemline receives an exclusive, worldwide license to develop, manufacture and commercialize GIM-621. Georgiamune will receive $45 million in upfront and near-term payments. Georgiamune is also eligible for preclinical, development, regulatory and commercial milestone payments, for a total potential deal value of up to $1.1 billion, plus royalties.
"At Georgiamune, we are focused on uncovering novel mechanisms that control immune-cell function and translating that biology into first-in-class medicines across autoimmune disease and oncology," said Samir N. Khleif, M.D., Founder and Chief Executive Officer of Georgiamune. "GIM-621 is one of multiple programs to emerge from that work, alongside three programs already in clinical development across autoimmune disease and oncology. This agreement brings Menarini's global oncology development and commercial capabilities to GIM-621 while allowing Georgiamune to continue advancing a broad pipeline built on distinct immune mechanisms."
"We are delighted to partner with Georgiamune, a company with deep expertise in immuno-oncology which has led to the discovery of GIM-621, a first-in-class oral immunotherapy with promise across multiple solid tumors," said Elcin Barker Ergun, CEO of the Menarini Group. "This program is a strong complement to our solid tumor portfolio, and our established oncology development and commercial capabilities position us well to accelerate its progress. We look forward to working closely with the Georgiamune team to unlock the full potential of this innovative approach to benefit patients with cancer."
About Georgiamune Georgiamune is a clinical-stage biotechnology company discovering and developing first-in-class therapies designed to reprogram immune signaling pathways to treat cancer and autoimmune disease. The company's research focuses on novel mechanisms that govern T-cell activation, regulatory T-cell function and immune homeostasis. Georgiamune has three clinical-stage programs: GIM-407, an oral Treg activator in autoimmune disease; GIM-122, a dual-functioning antibody in oncology; and GIM-531, an oral Treg inhibitor in oncology. Georgiamune is also advancing a broader pipeline of preclinical candidates across oncology and autoimmune disease, including GIM-621. The company was founded by Dr. Samir N. Khleif based on discoveries from his laboratory into mechanisms that control immune responses. For more information, visit www.georgiamune.com .
About The Menarini Group The Menarini Group is a leading international pharmaceutical and diagnostics company, with a turnover of $5.5 billion and over 17,000 employees. Menarini is focused on therapeutic areas with high unmet needs with products for cardiology, oncology, pneumology, gastroenterology, infectious diseases, diabetology, inflammation, and analgesia. With 18 production sites and 9 Research and Development centers, Menarini's products are available in 140 countries worldwide. For further information, please visit www.menarini.com .
About Stemline Therapeutics Inc. Stemline Therapeutics, Inc. ("Stemline"), a wholly-owned subsidiary of the Menarini Group, is a commercial-stage biopharmaceutical company focused on bringing transformational oncology treatments to patients. Stemline commercializes elacestrant, an oral endocrine therapy indicated for the treatment of postmenopausal women or adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy, in the U.S., Europe, and other global regions. Stemline also commercializes tagraxofusp-erzs, a novel targeted therapy directed to CD123, for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive hematologic cancer, in the United States, Europe, and other global regions. In addition, Stemline commercializes selinexor, an XPO1 inhibitor for multiple myeloma, in Europe. The company is also conducting multiple label-expansion studies with elacestrant and tagraxofusp in breast and hematologic cancer indications, respectively, and has an extensive clinical pipeline of additional drug candidates in various stages of development for a host of solid and hematologic cancers.
https://www.prnewswire.co.uk/news-releases/georgiamune-and-menarini-group-enter-exclusive-global-license-and-collaboration-agreement-for-gim-621-a-first-in-class-oral-immuno-oncology-agent-302917069.html
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