A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
Line Number: 127
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$hooks is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$config is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$log is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$utf8 is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$uri is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$exceptions is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$router is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$output is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$security is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$input is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$lang is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$load is deprecated
Filename: core/Controller.php
Line Number: 78
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$db is deprecated
Filename: core/Loader.php
Line Number: 396
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
Line Number: 371
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$table is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 132
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 292
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 166
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 235
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 315
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 356
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 289
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$session is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$agent is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$news_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$home_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Facebook\FacebookApp implements the Serializable interface, which is deprecated. Implement __serialize() and __unserialize() instead (or in addition, if support for old PHP versions is necessary)
Filename: Facebook/FacebookApp.php
Line Number: 29
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/libraries/Facebook/php-graph-sdk-5.x/php-graph-sdk-5.x/src/Facebook/FacebookApp.php
File: /home/judfadzm/public_html/healthtechseries.com/application/libraries/Facebook/php-graph-sdk-5.x/php-graph-sdk-5.x/src/Facebook/autoload.php
File: /home/judfadzm/public_html/healthtechseries.com/application/libraries/Facebook/php-graph-sdk-5.x/php-graph-sdk-5.x/src/Facebook/Facebook.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$facebook is deprecated
Filename: controllers/News.php
Line Number: 31
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$benchmark is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$hooks is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$config is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$log is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$utf8 is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$uri is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$exceptions is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$router is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$output is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$security is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$input is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$lang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$load is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$db is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$table is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$session is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$agent is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$news_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$home_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$facebook is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/application/controllers/News.php
File: /home/judfadzm/public_html/healthtechseries.com/index.php
Sirolimus-Coated Balloon Matches Drug-Eluting Stent at One Year in Large International TRANSFORM II Trial
Late-breaking results presented at TCT 2026 show an implant-free strategy with MagicTouch Sirolimus Coated Balloon is non-inferior to everolimus-eluting in de novo coronary artery disease
TAMPA, Florida , Nov. 2, 2026 /PRNewswire/ -- Sirolimus-coated balloon (SCB) strategy was non-inferior to contemporary everolimus-eluting stents (EES) for Target Lesion Failure (TLF) at 12 months in patients with de novo coronary artery disease. These are the results of the TRANSFORM II randomised trial, presented today as a Late-Breaking Clinical Trial at TCT 2026 and accepted in The Lancet which confirm how MagicTouch Sirolimus Coated Balloon (Concept Medical) matches contemporary best in class stent.
TRANSFORM II is an investigator-initiated, open-label, non-inferiority trial. It enrolled 1,842 patients in 53 centres in 11 countries across Europe, Asia and South America. Patients with a de novo native coronary lesion (vessel diameter 2.0 to 3.5 mm, lesion length ?50 mm) were randomised 1:1 to the MagicTouch SCB (Concept Medical ), with bailout stenting if needed, or to EES implantation. Randomisation took place only after successful lesion preparation, as recommended by the Drug-Coated Balloon Academic Research Consortium. The population was highly complex; nearly half of patients presented with an acute coronary syndrome, more than a third had diabetes and about a third were at high bleeding risk.
At 12 months, TLF occurred in 2.1% of patients in the SCB group and 2.4% in the EES group (hazard ratio 0.86; 95% CI 0.47–1.59). Target Lesion Failure was defined as a composite of cardiac death, target-vessel myocardial infarction and ischaemia-driven target lesion revascularisation. The risk difference of ?0.40 percentage points had a one-sided upper bound of 0.78 points, well below the prespecified 1.5 point margin (P=0.004 for non-inferiority). The result was consistent in the per-protocol and device-received analyses and across prespecified subgroups.
Bailout stenting was needed in only 7.6% of patients assigned to the SCB arm, much less often than in earlier large trials where randomisation came before lesion preparation. No definite or probable lesion thrombosis occurred in the SCB group, compared with 0.2% in the EES group. Net adverse clinical events, including bleedings, were numerically lower with SCB (4.1% vs 5.3%; HR 0.77; 95% CI 0.50–1.17), and rates of death, myocardial infarction, stroke and major bleeding were low and similar in both groups.
Any target lesion revascularisation was more frequent with SCB (2.5% vs 1.1%). However, ischaemia-driven revascularisation was similar in both groups (0.9% vs 0.8%).
"TRANSFORM II shows that when a lesion is well prepared, treating it with a sirolimus-coated balloon, without leaving a permanent metal implant, gives one-year clinical outcomes comparable to a modern drug-eluting stent," said Bernardo Cortese, MD, Principal Investigator and Study Chair, Fondazione Ricerca e Innovazione Cardiovascolare , Milan. "Drug-coated balloon angioplasty should be seen as a strategy, not a simple device swap. Careful lesion preparation and readiness to stent when needed are central to its success."
The investigators noted that event rates were lower than expected, that the results apply to lesions suitable for successful preparation and do not cover severely calcified, left main, thrombotic or STEMI lesions, and that the centres taking part were experienced in drug-coated balloon PCI. Follow-up will continue to five years to find out whether avoiding a permanent implant reduces very late device-related events.
Permanent metal caging with DES has been long sought as something to avoid and the robust evidence from TRANSFORM II has provided insights proving to be a turning point in current PCI practice, which should not rely solely on stents.
The trial was sponsored by Fondazione Ricerca e Innovazione Cardiovascolare ETS, Milan, Italy, with an unrestricted research grant from Concept Medical, which had no role in the trial's design, analysis or reporting. ClinicalTrials.gov: NCT04893291 .
Source: Data from TRANSFORM II, presented as a Late-Breaking Clinical Trial at the TCT USA Conference by Prof. Bernardo Cortese on November 01, 2026 and accepted in The Lancet.
MagicTouch is CE-marked. CAUTION: Investigational device in the United States, limited by Federal law to investigational use.
About Fondazione Ricerca e Innovazione Cardiovascolare
Fondazione RIC is an independent nonprofit foundation that accelerates independent investigator-driven cardiovascular research worldwide and is based in Italy and the Unites States. Founded in 2020, it gives transparent and reliable support to deliver high-quality clinical trials. With 19 clinical trials designed and conducted, 187 enrolling centers and >8000 patients enrolled, Fondazione RIC is one of the largest and most impactful cardiovascular organizations of the world. For more information, visit our website https://www.fondazioneric.org or reach out to segreteria@fondazioneric.org .
About MagicTouch SCB
The MagicTouch SCB , developed by Concept Medical Inc., utilizes proprietary Nanoluté technology to deliver sub-micron particles of sirolimus encapsulated in a biocompatible carrier, ensuring deep penetration into the vessel wall. The device has received CE Mark approval in Europe and Breakthrough Device Designation from the U.S. FDA for the treatment of small coronary vessels and in-stent restenosis. MagicTouch has also received IDE approvals for in-stent restenosis and small vessel treatment with trials ongoing for both indications.
About Concept Medical Inc.
Concept Medical Inc., headquartered in Tampa, Florida, has a global presence and is dedicated to enhancing patient care through cutting-edge research and development of drug-delivery technologies. Its proprietary platforms are designed to deliver pharmaceutical agents across vascular luminal surfaces with unparalleled precision. Concept Medical is the developer of the MagicTouch family of Sirolimus-Coated Balloons (SCB) – the world's first and most utilized SCB technology – well recognized for its versatility and efficacy in treating coronary and peripheral artery disease. The revolutionary MagicTouch and Abluminus product lines have been used to treat over a million patients globally, setting a new standard for vascular therapy.
For more information, please visit www.conceptmedical.com .
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